Peptide inhibitors of insulin-degrading enzyme
AssigneeThe Regents of the University of California
InventorMalcolm A. Leissring
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Abstract
The present disclosure describes novel peptides, including peptides that inhibit the proteolytic activity of insulin-de-grading enzyme (IDE). Also described are cosmetic and pharmaceutical formulations including these peptides, as well as a treatment method aimed at improving the appearance and/or texture of skin and/or promoting wound healing and a method for treating diabetes. The disclosed peptides and formulations are particularly useful for addressing the problem of impaired wound healing in diabetes.
Claims25
An:
- isolated peptide of 30 amino acid residues or less, wherein the peptide comprises a peptide amino acid sequence, said peptide amino acid sequence comprising or consisting of an amino acid sequence having at least 80% sequence identity to an amino acid sequence selected from the group consisting of:
- QSLPWCYPHCVT (SEQ ID NO:1),
- ACSWWSIHLCG (SEQ ID NO:3), and
- WSPISGKFFQRF (SEQ ID NO:4);
- or
- isolated peptoid thereof.
A method of improving the appearance and/or texture of skin and/or promoting wound healing in a living subject, wherein the method comprises topically administering a peptide or peptoid to the skin of the subject, wherein:
- the peptide is 30 amino acid residues or less and comprises a peptide amino acid sequence, said peptide amino acid sequence comprising or consisting of an amino acid sequence having at least 80% sequence identity to an amino acid sequence selected from the group consisting of:
- (SEQ ID NO:
- 1)
- QSLPWCYPHCVT,
- (SEQ ID NO:
- 2)
- VHWDFRQWWQPS,
- (SEQ ID NO:
- 3)
- ACSWWSIHLCG,
- and
- (SEQ ID NO:
- 4)
- WSPISGKFFQRF;
- and
- the peptoid is a peptoid of said peptide.
A method of treating diabetes, wherein the method comprises administering an effective amount of a peptide or peptoid to a subject having diabetes, wherein:
- the peptide is 30 amino acid residues or less and comprises a peptide amino acid sequence, said peptide amino acid sequence comprising or consisting of an amino acid sequence having at least 80% sequence identity to an amino acid sequence selected from the group consisting of:
- (SEQ ID NO:
- 1)
- QSLPWCYPHCVT,
- (SEQ ID NO:
- 2)
- VHWDFRQWWQPS,
- (SEQ ID NO:
- 3)
- ACSWWSIHLCG,
- and
- (SEQ ID NO:
- 4)
- WSPISGKFFQRF.
- and
- the peptoid is a peptoid of said peptide.
Dependencies are inferred from the claim text.