Diamide antimicrobial agents

A compound of Formula I

• wherein:
• R1 represents aryl, wherein aryl is substituted with 1 to 3 substituents selected from a group consisting of H, —X, S(C1-6 alkyl), O(C1-6 alkyl), and CX3;
• R2 is selected from the group consisting of C1-C8 alkyl, C3-C8 cycloalkyl, C3-C8 hetero cycloalkyl, and polyethyleneglycol, wherein each of said R2 groups are independently substituted with 1-3 substituents selected from a group consisting of C1-C6 alkyl, H, C1-C6 alkenyl, (CH2—O—(CH2)1-4)6—OH, C1-C6 alkynyl, OH, O(C1-C6 alkyl), F, Cl, Br, I, NO2, —C(═O)H, —C(═O)OH, —C(═O)O(C1-C6 alkyl), —C(═O)NH2, —C(═O)NH(C1-C6 alkyl), and —C(═O)N(C1-C6 alkyl)(C1-C6 alkyl);
• R3 is selected from a group consisting of C1-6 alkyl-NH2, CH(CH3)—NH2, CH(CH2CH2CH3)—NH2, CH(CH2CH2CH2CH3)—NH2, (CH2)0-3— C3-C8 hetero cycloalkyl wherein each R3 group is independently substituted with 1-3 substituents independently selected from a group consisting of H, C1-C6 alkyl, OH, O(C1-C6 alkyl), F, Cl, Br, I, NO2, —C(═O)H, —C(═O)OH, —C(═O)O(C1-C6 alkyl), —C(═O)NH2, —C(═O)NH(C1-C6 alkyl), and —C(═O)N(C1-C6 alkyl)(C1-C6 alkyl);
• R4 is selected from the group consisting of C1-C6 alkyl, C3-C8 cycloalkyl, arylalkyl, and heteroaryl-alkyl, wherein each of the R4 groups is independently substituted with 1-3 substituents independently selected from the group consisting of C1-C6 alkyl, H, OH, O(C1-C6 alkyl), F, Cl, Br, I, NO2, —C(═O)H, —C(═O)OH, —C(═O)O(C1-C6 alkyl), —C(═O)NH2, —C(═O)NH(C1-C6 alkyl), and —C(═O)N(C1-C6 alkyl)(C1-C6 alkyl);
• R5 is H or methyl;
• and
• X is selected from Cl, I, Br, and F.