2-(substituted benzene matrix) aromatic formate FTO inhibitor, preparation method therefor, and applications thereof

A compound of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof,

• wherein,
• each of A2 and A3 is CR′, and A1 and A4 are independently CR′ or N;
• or each of A1 and A3 is CR′, and A2 and A4 are independently CR′ or N;
• M is selected from the group consisting of CR′2, NH, O and S;
• R′ is selected from the group consisting of H, halogen atom, carbonyl (═O), carboxyl, and hydroxy;
• X has a structure selected from the group consisting of:
• carboxyl, hydroxamic acid group, substituted or unsubstituted C2-C12 ester group, substituted or unsubstituted amide group, and substituted or unsubstituted 3-12 membered heterocyclic group;
• Y is selected from the group consisting of substituted or unsubstituted C6-C12 aryl, and substituted or unsubstituted 3-12 membered heterocyclic group, wherein the substituted C6-C12 aryl is substituted with a substituent selected from the group consisting of hydroxy, carboxyl, and substituted or unsubstituted C1-C10 alkyl;
• and
• Ra and Rb are independently selected from the group consisting of halogen, —OH, NH2, and substituted or unsubstituted C1-C6 alkyl;
• Rc and Rd are independently selected from the group consisting of H, halogen, —OH, CN, NO2, NH2, substituted or unsubstituted C1-C6 alkyl, and substituted or unsubstituted C1-C6 alkoxy.