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US 11,555,007 B2Granted
Compositions and methods for the treatment of neurological diseases
AssigneeCellix Bio Private Limited
InventorMahesh Kandula
Life of this patent
Estimating the term…
Abstract
The invention relates to the compounds or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, formula II and formula III and the methods for the treatment of neurological diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, lozenge, spray, intravenous, oral solution, nasal spray, oral solution, suspension, oral spray, buccal mucosal layer tablet, parenteral administration, syrup, or injection. Such compositions may be used to treatment of neurological diseases.
Claims21
A compound of Formula I
- wherein
- RH is caprylic acid, adipic acid, capric acid, caproic acid, cinnamic acid, cyclamic acid, dodecylsulfuric acid, galactaric acid, gentisic acid, glucuronic acid, glutaric acid, glycerophosphoric acid, malonic acid, nicotinic acid, oleic acid, oxalic acid, palmitic acid, sebacic acid, omega 3 fatty acids, omega 6 fatty acids, n-acetyl cysteine, caprilic acid, alpha lipoic acid, R-lipoic acid, myristic acid, myristoleic acid, palmitoleic acid, phospholipids, phosphatidylcholine, elaidic acid, linoleic acid, linolenic acid, menthol, retinoic acid, vitamin A, retinol, linolelaidic acid, arachidonic acid, retinal, isotretinoin, curcumin, tretinoin, α-carotene, β-carotene, d2 ergosterol, ergocalciferol, 7-dehydrocholesterol, cholecalciferol, 25-hydroxycholecalciferol, calcitriol (1,25-dihydroxycholecalciferol), calcitroic acid, d4 dihydroergocalciferol, alfacalcidol, dihydrotachysterol, calcipotriol, tacalcitol, paricalcitol, tocopherol, naphthoquinone, phylloquinone, menaquinones, menadione, menadiol, thiamine, acefurtiamine, allithiamine, benfotiamine, fursultiamine, octotiamine, prosultiamine, sulbutiamine, riboflavin, niacin, nicotinamide, dexpanthenol, pantethine, pyridoxine, pyridoxal phosphate, pyridoxamine, pyritinol, biotin, folic acid, dihydrofolic acid, folinic acid, levomefolic acid, adenosylcobalamin, cyanocobalamin, hydroxocobalamin, methylcobalamin, choline, dehydroascorbic acid, 1-docosanol or
- wherein, each of R1, R2 and R3 is independently
- or a pharmaceutically acceptable hydrate, solvate, enantiomer, and stereoisomer thereof.
1 more element
A compound of Formula II
- wherein
- RH is caprylic acid, adipic acid, capric acid, caproic acid, cinnamic acid, cyclamic acid, dodecylsulfuric acid, galactaric acid, gentisic acid, glucuronic acid, glutaric acid, glycerophosphoric acid, malonic acid, nicotinic acid, oleic acid, oxalic acid, palmitic acid, sebacic acid, undecylenic acid, omega 3 fatty acids, omega 6 fatty acids, n-acetyl cysteine caprilic acid, alpha lipoic acid, R-lipoic acid, myristic acid, myristoleic acid, palmitoleic acid, phospholipids, phosphatidylcholine, elaidic acid, linoleic acid, linolenic acid, menthol, retinoic acid, vitamin A, retinol, linolelaidic acid, arachidonic acid, retinal, isotretinoin, curcumin, tretinoin, α-carotene, β-carotene, d2 ergosterol, ergocalciferol, 7-dehydrocholesterol, cholecalciferol, 25-hydroxycholecalciferol, calcitriol (1,25-dihydroxycholecalciferol), calcitroic acid, d4 dihydroergocalciferol, alfacalcidol, dihydrotachysterol, calcipotriol, tacalcitol, paricalcitol, tocopherol, naphthoquinone, phylloquinone, menaquinones, menadione, menadiol, thiamine, acefurtiamine, allithiamine, benfotiamine, fursultiamine, octotiamine, prosultiamine, sulbutiamine, riboflavin, niacin, nicotinamide, dexpanthenol, pantethine, pyridoxine, pyridoxal phosphate, pyridoxamine, pyritinol, biotin, folic acid, dihydrofolic acid, folinic acid, levomefolic acid, adenosylcobalamin, cyanocobalamin, hydroxocobalamin, methylcobalamin, choline, dehydroascorbic acid, 1-docosanol or
- wherein, each of R1, R2 and R3 is independently
- or a pharmaceutically acceptable hydrate, solvate, enantiomer, and stereoisomer thereof.
1 more element
Dependencies are inferred from the claim text.