# US 11,554,133 B2 · Bile acid synthesis promoter, composition for promoting bile acid synthesis and food composition for promoting bile acid synthesis

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- Number: US 11,554,133 B2
- Document ID: US11554133B2
- Status: Granted
- Kind: B2
- Application number: 17/171,545
- Filed: 2021-02-09
- Published: 2021-06-03
- Granted: 2023-01-17
- Earliest claimed: 2017-03-16
- Assignees: Kracie Holdings, Ltd.
- Applicants: Kracie Holdings, Ltd.
- Inventors: Shimpei Watanabe; Satoshi Inamasu; Mitsuhiro Watanabe; Yoko Takashina
- Web page: https://patentgrep.com/patent/US11554133B2

## CPC

- A61K 31/7048: having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin {, digitoxin or digoxin}
- A61P 9/10: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A23L 33/105: Plant extracts, their artificial duplicates or their derivatives
- A61K 9/1623: {Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules}
- A61K 9/2054: {Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose}
- A61K 31/341: not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
- A61K 31/365: Lactones
- A61K 36/28: Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K 36/634: Forsythia
- A61P 1/16: for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A61P 3/06: Antihyperlipidemics
- A61K 2236/331: using water, e.g. cold water, infusion, tea, steam distillation or decoction
- A61K 2236/333: using mixed solvents, e.g. 70% EtOH
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)

## Abstract

[Problem] To provide a novel medicine that is capable of promoting cholesterol metabolism to thereby treat, ameliorate or prevent various symptoms associated with increase in blood cholesterol level. [Solution] The present inventors newly found that arctigenin has an effect of promoting the conversion of cholesterol into bile acid. The present invention provides a bile acid synthesis promoter, a composition for promoting bile acid synthesis and a food composition for promoting bile acid synthesis each comprising arctigenin and/or arctiin as active ingredient(s).

## Claims

### Claim 1

A method for promoting bile acid excretion comprising:
administering a pharmaceutically effective amount arctigenin and/or arctiin to a subject in need of such treatment, wherein the subject in need of such treatment is a person diagnosed with angina or cerebral hemorrhage.

### Claim 2 (depends on 1)

The method according to claim 1, comprising said arctigenin and/or arctiin as burdock, burdock fruit, burdock sprout or Forsythia fruit or extracts thereof.

### Claim 3 (depends on 1)

The method according to claim 1, comprising administering parenterally.

### Claim 4 (depends on 1)

The method according to claim 1, comprising administering orally.