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US 11,549,881 B2Granted
High efficiency optical detection of biomolecules in micro-capillaries
AssigneeThe Regents of the University of California
InventorHolger Schmidt
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AssigneeThe Regents of the University of California
InventorHolger Schmidt
Estimating the term…
Disclosed herein are systems, methods, and techniques for optical detection of analytes (e.g., biomarkers or other objects) using a liquid-core waveguide in which the analytes are suspended in a high-index liquid inside a liquid channel of the waveguide. The term “high-index” may indicate a refractive core index of the carrier liquid that is higher than or equal to that of one or more surrounding cladding layer(s) (e.g., ethylene glycol liquid inside a glass channel). In some embodiments, a method includes illuminating, by a light-source, one or more particles in a liquid-core waveguide, wherein the liquid-core waveguide comprises a first cladding layer having a first index of a refraction, and a hollow core comprising a liquid inside the hollow core, wherein the liquid has a second index of refraction higher than the first index of refraction; and detecting, by a detector, light emitted from the one or more particles.
A method for particle detection, the method comprising:
A particle detection system comprising:
Dependencies are inferred from the claim text.