Human alzheimer's disease and traumatic brain injury associated tau variants as biomarkers and methods of use thereof

A binding molecule

• wherein the binding molecule preferentially binds to human Alzheimer's Disease (AD)-associated tau and comprises an amino acid sequence at least 95% identical to:
• (a) an antibody heavy chain variable domain and light chain variable domain of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:18, SEQ ID NO:20, SEQ ID NO:22, SEQ ID NO:24, SEQ ID NO:26, SEQ ID NO:28, SEQ ID NO:30, SEQ ID NO:32, SEQ ID NO:34, SEQ ID NO:36, SEQ ID NO:38, or SEQ ID NO:40;
• or
• (b) a DARPin of SEQ ID NO:8;
• wherein differences from the heavy chain variable domain and light chain variable domain of (a) or the DARPin of (b) are conservative substitutions.