DbpA antibodies and uses thereof
AssigneeQuidel Corporation
InventorsJason J. Sun, Jason McClure
Life of this patent
Estimating the term…
Abstract
Embodiments of the present disclosure relate to chimeric antibodies which specifically bind to Borrelia decorin-binding protein A (DbpA) antigens and compositions or kits comprising such antibodies. The disclosure further relates to use of such antibodies in the detection of Borrelia sp. in samples, e.g., biological samples such as human blood and/or tissues of deer, ticks and other carriers of Borrelia. Embodiments of the disclosure further relate to diagnosis and/or therapy of Lyme disease using the chimeric antibodies and/or compositions containing the chimeric antibodies.
Claims9
An antibody or an antigen-binding fragment thereof, comprising:
- a variable heavy chain region (VH) comprising heavy chain complementarity-determining regions CDRH1, CDRH2, and CDRH3, together with a variable light chain region (VL) comprising light chain complementarity-determining regions CDRL1, CDRL2, and CDRL3,
- wherein,
- CDRH1 has the amino acid sequence DYWIE (SEQ ID NO:
- 7);
- CDRH2 has the amino acid sequence EILPGSGSTKDNERFKG (SEQ ID NO:
- 8);
- CDRH3 has the amino acid sequence REWGYYFDY (SEQ ID NO:
- 9);
- CDRL1 has the amino acid sequence KASQDVSTAVA (SEQ ID NO:
- 10);
- CDRL2 has the amino acid sequence IYWASTRHT (SEQ ID NO:
- 11);
- and
- CDRL3 has the amino acid sequence QQHYSTPYT (SEQ ID NO:
- 12).
Dependencies are inferred from the claim text.