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US 11,548,919 B1Granted
SARS-CoV-2 polypeptide inhibitors directed against the Env TM domain and methods of treatment using said inhibitors
AssigneeKing Abdulaziz University
InventorsAlaa F. Nahhas, Thomas Webster
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Abstract
Methods for treating coronavirus infection, such as an infection caused by SARS-CoV-2, in a subject in need thereof include administering to the subject a therapeutically effective amount of a composition comprising an isolated polypeptide targeting the spike protein and the transmembrane region of the coronavirus envelope protein. Compositions include isolated polypeptides complementary to residues 30-38 of the envelope protein transmembrane region.
Claims11
An isolated polypeptide comprising the following amino acid sequence:
- NapFF-X1-L-X2-F-L-X3-X4-X5-E
- wherein
- X1, X3, and X5 are independently selected from T, S, and M;
- and
- X2 and X4 are independently selected from U and A.
2 more elements
Dependencies are inferred from the claim text.