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US 11,548,849 B2Granted
Alcohol derivatives as KV7 potassium channel openers
AssigneeH. Lundbeck A/S
InventorsMario Rottlander, Xiaofang Wang, Debasis Das, Jian Hong, Shu Hui Chen, Anette Graven Sams, Krestian Larsen
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Abstract
The present invention provides novel compounds (e.g., compounds of Formula I) which activate the Kv7 potassium channels. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders responsive to the activation of Kv7 potassium channels.
Claims9
A compound of Formula I
- wherein
- R1 is selected from the group consisting of C1-C6 alkyl, CF3, CH2CF3, CF2CHF2, and C3-C8 cycloalkyl, wherein said C3-C8 cycloalkyl may be substituted with 1 or 2 substituents selected from the group consisting of C1-C3 alkyl, F, CHF2 and CF3;
- and
- R2 is H, C1-C6 alkyl or CF3;
- or
- R1 and R2 combine to form C3-C5 cycloalkyl optionally substituted with 1 or 2 F, CHF2 or CF3;
- and
- R3 is C1-C3 alkyl, CH2O—C1-3 alkyl, or CH2O-cyclopropyl, wherein said C1-C3 alkyl or CH2O—C1-C3 alkyl is substituted with C≡N or C3-C5 cycloalkyl;
- and
- R4 is selected from the group consisting of OCF3, or OCHF2;
- or a pharmaceutically acceptable salt thereof.
8 more elements
Dependencies are inferred from the claim text.