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US 11,542,527 B2Granted
Parainfluenza virus 5 based vaccines
AssigneeUniversity of Georgia Research Foundation, Inc.
InventorBiao He
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Abstract
The present invention provides safe, stable, efficacious, and cost-effective vaccines based on viral expression vectors that include a parainfluenza virus 5 (PIV5) genome including a heterologous nucleotide sequence expressing a heterologous polypeptide.
Claims20
A viral expression vector comprising a parainfluenza virus 5 (PIV5) genome, the PIV5 genome comprising:
- a deletion of the gene encoding the small hydrophobic (SH) protein;
- and
- a heterologous nucleotide sequence expressing a heterologous polypeptide inserted within the PIV5 genome;
- and
- wherein the PIV5 genome lacks an SH protein.
2 more elements
Dependencies are inferred from the claim text.