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US 11,542,523 B2Granted
Animal cell, method for producing animal cell, and method for producing target protein
AssigneeFUJIFILM Corporation
InventorsTatsuya Matsuura, Tsukasa Ishihara
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Abstract
An object of the present invention is to provide an animal cell with improved proliferation ability and survival rate, a method for producing the animal cell, and a method for producing a target protein formed of the animal cell. According to the present invention, there is provided an animal cell having a gene encoding a target protein and a foreign gene encoding an isovaleryl-CoA dehydrogenase, in which the isovaleryl-CoA dehydrogenase is overexpressed.
Claims18
An animal cell that has an exogenous gene encoding a target protein and a foreign gene encoding an isovaleryl-CoA dehydrogenase,
- wherein the animal cell is a CHO cell,
- wherein the gene encoding the target protein and the foreign gene encoding isovaleryl-CoA dehydrogenase are present on the same expression vector, and
- wherein the gene encoding the target protein and the gene encoding isovaleryl-CoA dehydrogenous are operatively linked to different promoters.
Dependencies are inferred from the claim text.