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US 11,542,477 B2Granted
Virus-like particles co-expressing Toxoplasma gondii IMC, ROP18, and MIC8, and pharmaceutical composition comprising the same
AssigneeHealth Park Incorporated
InventorsHyunwoo Park, Hui Jin, Fu Shi Quan
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Abstract
The present invention relates to a virus-like particle for preventing or treating toxoplasmosis, comprising influenza virus matrix protein 1; and surface antigen proteins comprising an inner membrane complex, Rhoptry protein 18 and Microneme protein 8 derived from Toxoplasma gondii, and a pharmaceutical composition comprising the same.
Claims13
A virus-like particle, comprising:
- influenza virus matrix protein 1 (M1);
- and
- surface antigen proteins comprising an inner membrane complex (IMC), Rhoptry protein 18 (ROP18) and Microneme protein 8 (MIC8) derived from Toxoplasma gondii.
An expression vector for preparing a virus-like particle comprising a nucleic acid sequence of (SEQ ID NO:
- 5) encoding influenza virus matrix protein 1 (M1);
- a nucleic acid sequence of (SEQ ID NO:
- 6) encoding an inner membrane complex (IMC);
- a nucleic acid sequence of (SEQ ID NO:
- 7) encoding Rhoptry protein 18 (ROP18);
- and a nucleic acid sequence of (SEQ ID NO:
- 8) encoding Microneme protein 8 (MIC8).
4 more elements
A host cell transformed with the expression vector of claim wherein the host cell is a non-human cell.
Dependencies are inferred from the claim text.