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US 11,542,233 B2Granted
Compounds, compositions and methods of use
AssigneeAquinnah Pharmaceuticals, Inc.
InventorsDuane A. Burnett, Joseph P. Vacca
Life of this patent
Estimating the term…
Abstract
Herein, compounds, compositions and methods for modulating inclusion formation and stress granules in cells related to the onset of neurodegenerative diseases, musculoskeletal diseases, cancer, ophthalmological diseases, and viral infections are described.
Claims27
A compound of Formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- Ring A is cycloalkyl or aryl;
- Ring B is indolyl or benzimidazolyl;
- X is C(R′)(R″);
- L1 is —NHCH2;
- L2 is —C(O)NRA—;
- each of R1 and R3 is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 heteroalkyl, C1-C6 haloalkyl, halo, cyano, nitro, azido, cycloalkyl, —ORB, —C(O)RD, —C(O)ORB, —NRARC, —NRAC(O)RD, —S(O)xRE, —OS(O)xRE, —C(O)NRAS(O)xRE, —NRAS(O)xRE, or —S(O)xNRA, each of which is optionally substituted with 1-5 R5;
- or
- each R2 is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 heteroalkyl, C1-C6 haloalkyl, halo, cyano, or nitro;
- each of R′ and R″ is independently H, C1-C6 alkyl, or C1-C6 heteroalkyl;
- each R5 is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 heteroalkyl, C1-C6 haloalkyl, halo, cyano, or oxo;
- or two R5, taken together with the atoms to which they are attached, form a ring, optionally substituted with 1-5 R6;
- each RA, RB, RC, RD, or RE is independently H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 heteroalkyl, C1-C6 haloalkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl, each of which is optionally substituted with 1-4 R6;
- or RA and RC, together with the atoms to which each is attached, form a heterocyclyl ring;
- each R6 is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 heteroalkyl, C2-C6 heteroalkenyl, C2-C6 heteroalkynyl, C1-C6 haloalkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, halo, cyano, or nitro;
- each of n, o, and p is independently 0, 1, 2, 3, 4, 5, or 6;
- and
- x is 0, 1, or 2.
15 more elements
Dependencies are inferred from the claim text.