Electrospun material covered medical appliances and methods of manufacture
AssigneeMerit Medical Systems, Inc.
InventorsJohn William Hall, Bart Dolmatch, Zeke Eller, Robert S. Kellar, Rachel Lynn Simmons, Wayne L. Mower
Life of this patent
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Abstract
A medical appliance or prosthesis may comprise one or more layers of electrospun nanofibers, including electrospun polymers. The electrospun material may comprise layers including layers of polytetrafluoroethylene (PTFE). Electrospun nanofiber mats of certain porosities may permit tissue ingrowth into or attachment to the prosthesis.
Claims18
A method for inhibiting a neointimal hyperplasia response to an implantable medical appliance, comprising implanting the medical appliance into a patient, the medical appliance coated with a first electrospun polytetrafluoroethylene (PTFE) layer comprising a porous mat and a second non electrospun polymer layer of fluorinated ethylene propylene (FEP) that is impervious to tissue ingrowth into the second polymer layer, wherein:
- the implantable medical appliance comprises a tubular medical device;
- the second polymer layer is disposed around the first electrospun PTFE layer;
- the first electrospun PTFE layer defines an inside surface of the tubular medical device;
- wherein the first electrospun PTFE layer is sintered,
- wherein the second polymer layer is nonporous and non-fibrous,
- wherein the medical appliance is coated with a third polymer layer comprising electrospun PTFE, such that the FEP is disposed between the first and third layers, and
- wherein the combined thickness of the layers is between about 20 micrometers and 100 micrometers.
A method for inhibiting a neointimal hyperplasia response to an implantable medical appliance, comprising implanting the medical appliance into the vasculature of a patient, the medical appliance comprising a first electrospun PTFE layer, wherein the first electrospun PTFE layer is sintered, and a second non-electrospun polymer layer of fluorinated ethylene propylene (FEP) that is impervious to tissue ingrowth into the second polymer layer, wherein the implantable medical appliance is implanted such that the first electrospun PTFE layer is in contact with blood flowing through the patient's vasculature, wherein the second polymer layer is nonporous and non-fibrous, wherein the medical appliance is coated with a third polymer layer comprising electrospun PTFE, such that the FEP is disposed between the first and third layers, and wherein the combined thickness of the layers is between about 20 micrometers and 100 micrometers.
A method for inhibiting a neointimal hyperplasia response to an implantable medical appliance, comprising:
- implanting the medical appliance into a patient, the medical appliance coated with a first electrospun polytetrafluoroethylene (PTFE) layer comprising a porous mat and a second non- electrospun polymer layer of fluorinated ethylene propylene (FEP) that is impervious to tissue ingrowth into the second polymer layer;
- wherein the second polymer layer is disposed around the first electrospun PTFE
- wherein the first electrospun PTFE layer defines an inside surface of the tubular medical device;
- wherein the first electrospun PTFE layer is stretched,
- wherein the second polymer layer is nonporous and non-fibrous,
- wherein the medical appliance is coated with a third polymer layer comprising electrospun PTFE, such that the FEP is disposed between the first and third layers, and
- wherein the combined thickness of the layers is between about 20 micrometers and 100 micrometers.
Dependencies are inferred from the claim text.