Noncrushable pill formulations
AssigneeThe Regents of the University of California
InventorsHeather D. Maynard, Natalie Boehnke, Samantha J. Paluck
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Abstract
Non-crushable pill formulations and methods of using the formulations are disclosed. A non-crushable pill formulation for preventing unintended use of a drug, comprising a polymer, the polymer forming a polymer backbone of the complex; cross-linkers, the cross-linkers connecting the polymer backbone through covalently bonding to form at least one inner cavity within the complex; and the drug, the drug being trapped either covalently or non-covalently in the at least one inner cavity within the complex, wherein the drug is protected from releasing outside of the complex.
Claims18
A complex for preventing unintended use of a drug, the complex comprising:
- an enzyme responsive peptide;
- a polymer, the polymer forming a polymer backbone of the complex;
- cross-linkers, the cross-linkers connecting the polymer backbone through covalently bonding to form at least one inner cavity within the complex;
- and
- the drug, the drug being trapped either covalently or non-covalently in the at least one inner cavity within the complex,
- wherein the drug is protected from releasing outside of the complex and
- wherein the enzyme responsive peptide comprises an amino acid having an α-amino group, an α-carboxylic acid group and an ε-amine group covalently bonded with an enzyme substrate comprising phenylalanine, tyrosine, or tryptophan, wherein the α-amino group is covalently bonded with a second amino acid or a peptide, and the α-carboxylic acid is covalently bonded with a first group.
Dependencies are inferred from the claim text.