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AssigneeMvrix Co., Ltd.
InventorsDae-Hyuk Kweon, Byoungjae Kong, Woo-Jae Chung, Baik Lin Seong, Sukchan Lee
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The present invention relates to a nanoperforator having a lipid-bilayer nanodisc and a membrane-structured protein surrounding the nanodisc and to a pharmaceutical composition having the nanoperforator as an active ingredient for preventing or treating viral infectious diseases. The use of the lipid-bilayer nanoperforator provided in the present invention can lead to the safe prevention or treatment of a disease caused by viral infection regardless of whether the virus is a variant or not, and thus the present invention can be widely used for the safe and effective treatment of viral infectious diseases.
A method of treating a viral infection, the method comprising administering a pharmaceutically effective amount of an active ingredient of a nano-perforator comprising a lipid bilayer nanodisc, a membrane scaffold protein surrounding an outer circumferential surface of the nanodisc, and a receptor for a surface antigen of a virus to a subject having a viral infection, wherein the nano-perforator excludes a nano-perforator comprising 1-palmitoyl-2-oleoyl-sn-glycero-3 [phospho-rac-(1-glycerol)] (POPG) lacking the receptor for the surface antigen of the virus.
Dependencies are inferred from the claim text.