High penetration compositions and their applications

A compound of Structure P4-3:

• wherein:
• T is selected from the group consisting of
• L41 is selected from the group consisting of N and N-L3;
• wherein L3 is selected from the group consisting of C1-C12 alkylene, C3-C12 cycloalkylene, C3-C12 heterocycloalkylene, arylene, heteroarylene, C1-C12 alkoxylene, C1-C12 alkylenethio, C1-C12 perfluoroalkylene, and C1-C12 alkylene halide;
• each Y1-Y11 is independently selected from the group consisting of H, CI, F, Br, I, CN, CH3C═C, CF3, CH3, CF3CF2, CH3CH2, CH3CH2CH2, (CH3)2CH, (CH3)2CHCH2, CH3CH2CH(CH3), (CH3)3C, C5H11, CH3CO, CH3CH2CO, CH3OC(═O), CH3CH2OC(═O), CH3COO, CH3COS, CH3O, HO, CF3CH2SCH2, CHCI2, CH3S, HS, CH3OCH2CH2, C2H5OCONH, CH3OCONH, CH3SO2, CH3SO, NH2SO2, C6H5CH2, NH2, cyclobutyl, cyclopropyl, 4-chlorophenyl, 4-fluorophenyl, CH2═CH, CH2═CHCH2, CH3CH═CH, and NO2;
• R is selected from the group consisting of C1-C12 alkylene, C3-C12 cycloalkylene, C3-C12 heterocycloalkylene, arylene, heteroarylene, C1-C12 alkoxylene, C1-C12 alkylenethio, C1-C12 perfluoroalkylene, and C1-C12 alkylene halide;
• each R1 and R2 is independently selected from the group consisting of H, C1-C12 alkyl, C3-C12 cycloalkyl, C3-C12 heterocycloalkyl, aryl, heteroaryl, C1-C12 alkoxyl, C1-C12 alkylthio, C1-C12 alkylamino, C1-C12 perfluoroalkyl, and C1-C12 alkyl halide;
• each R11-R13 is independently selected from the group consisting of nothing, C1-C12 alkylene, C3-C12 cycloalkylene, C3-C12 heterocycloalkylene, arylene, heteroarylene, C1-C12 alkoxylene, C1-C12 alkylenethio, C1-C12 alkyleneamino, C1-C12 perfluoroalkylene, and C1-C12 alkylene halide;
• and
• HA is a pharmaceutically acceptable acid.