Nick-based data storage in native nucleic acids
AssigneeThe Board of Trustees of the Univ. of Illinois
InventorsOlgica Milenkovic, Alvaro Gonzalo Hernandez, Seyed Kasra Tabatabaei, Huimin Zhao
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Abstract
Nick-based methods, devices, and systems for nick-based data storage in a deoxyribonucleic acid (DNA) sequence are disclosed. Digital information is encoded in a register of at least one copy of a double-stranded DNA sequence having a plurality of nickable positions. The data is translated into a sequence of values from a nick alphabet that is subsequently mapped to the plurality of nickable positions, and the DNA sequence is nicked according to the mapped values. Because the digital information is encoded as a series of nicked and non-nicked positions of a double-stranded DNA sequence, the nucleotide sequence of the DNA can be non-synthetic, or “native” DNA.
Claims13
A method for storing data, the method comprising:
- providing a register comprising a double-stranded deoxyribonucleic acid (DNA) sequence, wherein the DNA sequence has a plurality of nickable positions;
- translating the data into a sequence of values from a nick alphabet, wherein the nick alphabet comprises at least a first value and a second value, wherein the first value indicates not to nick the DNA sequence, wherein the second value indicates to nick the DNA sequence, and wherein the sequence of values includes at least one second value;
- mapping the sequence of values to the plurality of nickable positions;
- and
- nicking one strand of the DNA sequence at each nickable position having a mapped value that indicates to nick the DNA sequence in order to provide an encoded register.
Dependencies are inferred from the claim text.