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US 11,535,896 B2Granted
Method for analysing cell-free nucleic acids
AssigneeKatholieke Universiteit Leuven
InventorsLuc Dehaspe, Joris Vermeesch
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Abstract
The present invention concerns the analysis of cell-free nucleic acids to determine the contribution of cell-free nucleic acids from specific tissues. In addition, the invention provides methods for diagnosing diseases based on cell-free nucleic acid analysis. The methods of the invention are also useful to detect quality defects in samples containing cell-free nucleic acids.
Claims8
A method for determining a health status of a test individual, the method comprising:
- (a) providing from the test individual a biological sample comprising cell free nucleic acids (cfna);
- (b) determining within at least autosomes, a genome wide distribution of the cfna of the test individual over genomic locations of predetermined regions;
- (c) providing a set of genome wide reference distributions of cfna from a plurality of biological samples of reference individuals, wherein the plurality of reference individuals comprises reference individuals with a disease and healthy reference individuals;
- (d) clustering reference distributions of cfna of a plurality of reference individuals in a test specific reference distribution, wherein the test specific reference distribution is generated by combining the distributions of cfna reference samples which have the highest similarity to the distribution of cfna of the test sample;
- and
- (e) determining based on the similarity of the distribution of cfna of the test individual with the identified reference distribution that the test individual has the health status of the reference individual.
3 more elements
Dependencies are inferred from the claim text.