Methods of detecting lung cancer
AssigneesUniversity of Maryland, Baltimore, The United States Government as represented by the Department of Veterans Affairs
InventorFeng Jiang
Life of this patent
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Abstract
The present invention provides a method of predicting whether a pulmonary nodule in a subject is benign or non-small cell lung cancer, comprising obtaining the results of an assay that measures an expression level of miR205-5p in a plasma sample from the subject; obtaining the results of an assay that measures an expression level of miR126 in a plasma sample from the subject; obtaining the results of an assay that provides a size of the pulmonary nodule in the subject; and calculating a probability value based on the combination of the expression levels of miR205-5p and miR126, and the size of the pulmonary nodule, wherein if the probability value exceeds a specified threshold, the pulmonary nodule is predicted as non-small cell lung cancer.
Claims15
A method for efficiently targeting the treatment of non-small cell lung cancer in a subject exhibiting a pulmonary nodule, the method comprising
- a. performing an assay that measures an expression level of miR205-5p in a plasma sample from the subject;
- b. performing an assay that measures an expression level of miR126 in a plasma sample from the subject;
- c. performing an assay that provides a size of the pulmonary nodule in the subject;
- d. calculating a probability value based on the combination of the expression levels of miR205-5p and miR126, and the size of the pulmonary nodule;
- e. if the probability value is below a specified threshold, considering the pulmonary nodule to be benign and so notifying the subject;
- and
- f. if the probability meets or exceeds the specified threshold, administering a treatment for non-small cell lung cancer to the subject, wherein the treatment is selected from administration of a therapeutic agent, surgery, radiofrequency ablation, radiation, and combinations thereof.
Dependencies are inferred from the claim text.