Typing method

A method of identifying a human individual in need of therapy for Alzheimer's disease and treating the identified human individual, the method comprising:

• (A) assaying a blood sample from a human individual for ten chromosome interactions, wherein said assaying comprises the steps of:
• (a) performing in vitro cross-linking of chromosome regions of the human individual which have come together in a chromosome interaction to form cross- linked nucleic acid;
• (b) subjecting said cross-linked nucleic acid to restriction digestion cleavage with an enzyme to form cross-linked cleaved nucleic acids;
• (c) ligating said cross-linked cleaved nucleic acid ends to form a ligated nucleic acid;
• and
• (d) detecting the ligated nucleic acid to determine the presence or absence of a chromosome interaction and wherein the ten chromosome interactions are the following chromosomal interactions:
• (i) the chromosome interaction on chromosome 12 that results in a ligated nucleic acid comprising SEQ ID NO:
• 8;
• (ii) the chromosome interaction on chromosome 8 that results in a ligated nucleic acid comprising SEQ ID NO:
• 1;
• (iii) the chromosome interaction on chromosome 8 that results in a ligated nucleic acid comprising SEQ ID NO:
• 19;
• (iv) the chromosome interaction on chromosome 3 that results in a ligated nucleic acid comprising SEQ ID NO:
• 5;
• (v) the chromosome interaction on chromosome 8 that results in a ligated nucleic acid comprising SEQ ID NO:
• 2;
• (vi) the chromosome interaction on chromosome 10 that results in a ligated nucleic acid comprising SEQ ID NO:
• 24;
• (vii) the chromosome interaction on chromosome 9 that results in a ligated nucleic acid comprising SEQ ID NO:
• 6;
• (viii) the chromosome interaction on chromosome 11 that results in a ligated nucleic acid comprising SEQ ID NO:20;
• (ix) the chromosome interaction on chromosome 3 that results in a ligated nucleic acid comprising SEQ ID NO:21;
• and
• (x) the chromosome interaction on chromosome 7 that results in a ligated nucleic acid comprising SEQ ID NO:15;
• (B) identifying the human individual as being in need of therapy for Alzheimer's disease when one or more of chromosome interactions (i)-(vii) are present and/or one or more of chromosome interactions (viii)-(x) are absent;
• and
• (C) administering to the identified human individual an agent that is therapeutic for Alzheimer's disease.