Continuous analyte monitoring electrode with crosslinked enzyme
AssigneeRoche Diabetes Care, Inc.
InventorsReinhold Mischler, Angelika Fuerst, Daniel Kammerer
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Abstract
The present invention relates to an enzymatic electrode comprising a conductive surface and wherein a conjugate comprising at least one enzyme molecule is covalently bound to the conductive surface. The electrode is suitable for continuous analyte monitoring, particularly for continuous glucose monitoring (CGM) with glucose oxidase (GOD) as enzyme molecule. Further, the invention relates to an electrochemical sensor for measuring the concentration of an analyte, e.g. glucose under in vivo conditions comprising the enzymatic electrode.
Claims17
An electrode comprising a conductive surface and a conjugate comprising at least one enzyme molecule and at least one conductive nanoparticle covalently bound to each other, wherein the conjugate is covalently bound to the electrode surface via the at least one enzyme molecule and wherein the nanoparticle is not directly covalently bound to the conductive surface.
An electrode comprising:
- a conductive surface;
- and
- a conjugate comprising at least one enzyme molecule and at least one nanoparticle covalently bound to each other,
- wherein the at least one enzyme molecule, and not the nanoparticle, has free functional groups covalently bound to the conductive surface.
Dependencies are inferred from the claim text.