Nucleic acid compounds for binding growth differentiation factor 11
AssigneeSomaLogic Operating Co., Inc.
InventorsUrs Ochsner, Louis Green, Dom Zichi, Nebojsa Janjic
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Abstract
Described herein are aptamers capable of binding to growth differentiation factor 11 (GDF11) protein; compositions comprising a GDF11 binding aptamer with a GDF11 protein; and methods of making and using the same.
Claims24
An aptamer that binds human GDF11, wherein the aptamer comprises the sequence 5′-RWnMCnCPPGMmMPPPAnACnMCmRWnPPGnPASnGS-3′ (SEQ ID NO:
- 151), wherein:
- each P is independently, and for each occurrence, a C-5 modified pyrimidine;
- R is A or G;
- each W is independently, and for each occurrence, A, T, or U;
- each M is independently, and for each occurrence, A or C;
- each S is independently, and for each occurrence, G or C;
- each n is independently, and for each occurrence, 0 or 1;
- and
- each m is independently, and for each occurrence, 0 or 1.
An aptamer that binds human GDF11, wherein the aptamer comprises the sequence 5′-CPPGMPPPNxPPPAGC-3′ (SEQ ID NO:
- 160) or 5′-CPPGMPPPNxPPPAGG-3′ (SEQ ID NO:
- 116), wherein each P is independently, and for each occurrence, a C-5 modified pyrimidine, wherein x is 2, 3, 4, or 5, wherein M is C or A, and wherein each N is independently, and for each occurrence, selected from A, C, G, T, and U.
An aptamer that binds human GDF11, wherein the aptamer comprises the sequence 5′-NNCPPGRPPPAMGPPPAGS-3′ (SEQ ID NO:
- 141), wherein each P is independently, and for each occurrence, a C-5 modified pyrimidine, R is A or G;
- each N is independently, and for each occurrence, A, G, or C;
- M is A or C;
- and S is G or C.
An aptamer that binds GDF11, wherein the aptamer comprises a sequence selected from SEQ ID NOs:
- 12, 13, 15 to 109, 117 to 140, and 142 to 150.
Dependencies are inferred from the claim text.