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US 11,535,851 B2Granted
Reagents for treatment of hepatitis B virus (HBV) infection and use thereof
AssigneeBenitec IP Holdings Inc.
InventorsTin Mao, David Suhy
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Abstract
This disclosure relates to RNA interference (RNAi) reagents for treatment of hepatitis B virus (HBV) infection, compositions comprising same, and use thereof to treat individuals infected with HBV. The reagents are artificial miRNA (shmiRNA) used alone or in combination with additional shmiRNA or shRNA.
Claims23
A nucleic acid comprising a DNA sequence which encodes a short hairpin micro-RNA (shmiR), said shmiR comprising:
- an effector sequence of at least 17 nucleotides in length;
- an effector complement sequence;
- a stemloop sequence;
- and
- primary micro RNA (pri-miRNA) backbone;
- wherein the effector sequence is substantially complementary to a RNA transcript set forth in SEQ ID NO:
- 4;
- and wherein the shmiR inhibits or reduces expression of one or more Hepatitis B virus (HBV) genes in a cell by more than 60% relative to a cell in which the shmiR is absent.
5 more elements
Dependencies are inferred from the claim text.