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US 11,535,838 B2Granted
Serine protease molecules and therapies
AssigneeResearch Development Foundation
InventorsMichael G. Rosenblum, Khalid Amanali Mohamedali, Lawrence H. Cheung
Life of this patent
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Abstract
Cell-targeted serine protease constructs are provided. Such constructs can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). In some aspects, recombinant serine proteases, such as Granzyme B polypeptides, are provided that exhibit improved stability and cell toxicity. Methods and compositions for treating lapatinib or trastuzumab-resistant cancers are also provided.
Claims11
A cell-targeting polypeptide construct comprising, from N- to C-terminus:
- (a) a truncated serine protease having an IIGG, IVGG or ILGG at its N-terminus, the truncated serine protease having an amino acid sequence at least 95% identical to a SEQ ID NO:
- 1, SEQ ID NO:
- 46, SEQ ID NO:47, SEQ ID NO:
- 48, SEQ ID NO:49, SEQ ID NO:
- 50, SEQ ID NO:
- 51, SEQ ID NO:
- 52, SEQ ID NO:
- 53, SEQ ID NO:
- 54, SEQ ID NO:
- 55, SEQ ID NO:
- 56, SEQ ID NO:
- 57 or SEQ ID NO:
- 58;
- (b) an antibody heavy chain constant (Fc) domain;
- and
- (c) a cell-targeting cytokine domain.
13 more elements
Dependencies are inferred from the claim text.