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US 11,535,832 B2Granted
Esterases and uses thereof
AssigneeCarbios
InventorsBenoît David, Isabelle Andre, Maher Ben Khaled, Sophie Duquesne, Alain Marty
Life of this patent
Estimating the term…
Abstract
The present invention relates to esterases, more particularly to esterase variants having improved activity and/or improved themostability compared to the esterase of SEQ ID NO:1 and the uses thereof for degrading polyester containing material, such as plastic products. The esterases of the invention are particularly suited to degrade polyethylene terephthalate, and material containing polyethylene terephthalate.
Claims21
An esterase which (i) has at least 75% identity to the full length amino acid sequence set forth in SEQ ID NO:
- 1, and (ii) has at least one amino acid substitution at a position corresponding to residues selected from Q182, T11, R12, A14, W69, R73, A205, N214, A215, A216, I217, F238, V242, D244, P245, A246, L247, D94, R138, F187, P10, L15, D18, N87, S88, S95, Q99, K159, A125, and S218 wherein the positions are numbered by reference to the amino acid sequence set forth in SEQ ID NO:
- 1, and (iii) exhibits increased polyester degrading activity and/or an increased thermostability compared to the esterase of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.