Sickled beta globin antibodies
Assigneebluebird bio, Inc.
InventorOlivier Negre
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Abstract
The invention generally provides improved anti-sickled-globin antibodies and fragments thereof. In particular embodiments, the antibody or antigen binding fragment thereof recognizes the βs, Glu6Val mutation. In various embodiments, the invention provides a conjugate comprising an anti-βs-globin antibody or antigen binding fragment thereof and a detectable label. In particular embodiments, a hybridoma comprising an anti-βs-globin antibody contemplated herein is provided.
Claims5
An anti-βS globin antibody or antigen binding fragment thereof that binds a human βS globin polypeptide, wherein the anti-βS globin antibody or antigen binding fragment thereof comprises a variable light chain sequence as set forth in SEQ ID NO:
- 7 and a variable heavy chain sequence as set forth in SEQ ID NO:
- 8.
Dependencies are inferred from the claim text.