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US 11,535,669 B2Granted
Fusion constructs and methods of using thereof
AssigneePrecigen, Inc.
InventorsHelen Sabzevari, Simon Metenou, ChangHung Chen, Rutul R. Shah
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Abstract
Provided herein is a composition comprising a fusion protein or a fragment or a variant thereof comprising an anti-PD1 antibody or a fragment/variant thereof and a TGF-β trap. Provided herein is a composition comprising a fusion protein or a fragment thereof or a variant thereof comprising an anti-PD1 antibody or a fragment/variant thereof and a ADA2 polypeptide. Also provided herein are methods of using the composition in treating cancer.
Claims15
A fusion protein comprising:
- (a) an IgG4 antibody comprising:
- (i) a first polypeptide comprising an amino acid sequence that is at least 95% identical to SEQ ID NO:
- 6 or 7;
- (ii) a second polypeptide comprising an amino acid sequence that is at least 95% identical to SEQ ID NO:
- 12 or 13;
- and (iii) a third polypeptide comprising the amino acid sequence of SEQ ID NO:
- 146 but with a mutation at position 108 thereof;
- and
- (b) a fourth polypeptide comprising an amino acid sequence that is at least 95% identical to SEQ ID NO:
- 14;
- wherein one or more polypeptides of the fusion protein are connected by a linker.
8 more elements
Dependencies are inferred from the claim text.