Anti-CD3 antibodies and methods of making and using thereof
AssigneesSystimmune, Inc., Baili-Bio (Chengdu) Pharmaceutical Co., Ltd.
InventorsOle Olsen, Phil Tan, Dong Xia, David Jellyman, Brian Kovacevich, Bill Brady, Blair Renshaw, Zeren Gao, Yi Zhu
Life of this patent
Estimating the term…
Abstract
The applications provides the anti-CD3 monoclonal antibodies, antigen-binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to active CD3+ T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.
Claims17
An isolated monoclonal antibody (mAb) or antigen-binding fragment thereof having a binding specificity to human CD3, wherein the isolated mAb or antigen-binding fragment comprises an amino acid sequence of SEQ ID NO:
- 56.
An IgG1 heavy chains for an isolated mAb having a binding specificity to human CD3, comprising an amino acid sequence SEQ ID NO:
- 55.
A kappa light chain for an isolated mAb having a binding specificity to human CD3, comprising an amino acid sequence of SEQ ID NO:
- 51.
A variable light chain for an isolated mAb having a binding specificity to human CD3, comprising an amino acid sequence of SEQ ID NO:
- 52.
A variable heavy chain for an isolated mAb having a binding specificity to human CD3, comprising an amino acid sequence of SEQ ID NO:
- 56.
Dependencies are inferred from the claim text.