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US 11,535,661 B2Granted
RAGE fusion proteins with improved stability and ligand binding affinity and uses thereof
AssigneeBioAge Labs, Inc.
InventorsRobert Hughes, William Strohl
Life of this patent
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Abstract
The present invention provides soluble RAGE-Fc fusion proteins with increased stability and extended half-life capable of binding endogenous RAGE ligands with high apparent affinity. The present invention also provides methods of making and using stable, soluble RAGE-Fc fusion proteins. These soluble RAGE-Fc fusion proteins are useful as therapeutics based on their ability to bind endogenous RAGE ligands.
Claims18
An isolated polynucleotide encoding a polypeptide comprising:
- (a) a first domain having an amino acid sequence at least 97% identical to the sequence of SEQ ID NO:74;
- and
- (b) a second domain comprising a fragment of a Fc region of an immunoglobulin,
- wherein the carboxy terminus of said first domain is coupled to the amino terminus of said second domain by a peptide linkage, and
- wherein the polypeptide comprising the first domain and the second domain has an amino acid sequence selected from:
- SEQ ID NO:
- 12, SEQ ID NO:15, SEQ ID NO:
- 16, and SEQ ID NO:
- 53.
6 more elements
An isolated polynucleotide encoding a fusion protein, the isolated polynucleotide comprising:
- a nucleotide sequence selected from SEQ ID NO:
- 39, SEQ ID NO:
- 41, SEQ ID NO:
- 43, and SEQ ID NO:
- 56.
2 more elements
Dependencies are inferred from the claim text.