Cytokine combination
OwnerJinyu Zhanginventor
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OwnerJinyu Zhanginventor
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Provided is a cytokine combination for treating a tumor and/or preventing recurrence or metastasis of the tumor. The cytokine combination comprising at least three cytokines selected from the following groups: IL(interleukin)12 or a functional variant thereof, GMCSF (granulocyte-macrophage colony-stimulating factor) or a functional variant thereof, FLT3L (FMS-like tyrosine kinase 3 ligand) or a functional variant thereof, IL2 or a functional variant thereof, IL15 or a functional variant thereof, IL21 or a functional variant thereof, and IL7 or a functional variant thereof. Also provided is a nucleic acid molecule encoding the cytokine combination and a vector thereof, a cell, a pharmaceutical composition, and a application thereof for the manufacture of a drug for treating the tumor and/or preventing recurrence or metastasis of the tumor.
A pharmaceutical composition, comprising consisting of interleukin 12 (IL12), granulocyte macrophage colony stimulating factor (GMCSF), and interleukin 2 (IL2), and a pharmaceutically acceptable carrier, wherein the proportion of IL12, GMCSF and IL2 in the pharmaceutical composition is 5:1:1, 1:5:1, 1:1:5 or 1:1:1.
Dependencies are inferred from the claim text.