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US 11,535,649 B2Granted
Peptides and other agents for treating pain and increasing pain sensitivity
AssigneeThe Research Foundation for The State University of New York
InventorsArindam Bhattacharjee, Kerri Pryce
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Abstract
Described herein are peptides that can be used to treat pain or increase pain sensitivity in subject in need of treatment. Additionally, peptides of the present disclosure can be administered with an analgesic agent and/or anesthetic agent. Peptides of the present disclosure are suitable for use when a subject in need of treatment has an injury, a chronic disease, a chronic inflammation, Morton's neuroma, operative/post-operative pain, or a combination thereof.
Claims22
A peptide, consisting of an amino acid sequence of
- (SEQ ID NO:
- 75)
- X1X2X3X4X5X6PX7YX8X9VX10X11X12,
- wherein
- X1 is selected from the group consisting of S, P, and A;
- X2 is selected from the group consisting of T, S, and A;
- X3 is selected from the group consisting of A and T;
- X4 is selected from the group consisting of A, T, I, and S;
- X5 is selected from the group consisting of C, S, and F;
- X6 is selected from the group consisting of P and L;
- X7 is any amino add residue;
- X8 is selected from the group consisting of chosen from E, D and Y;
- X9 is selected from the group consisting of S and R;
- X10 is selected from the group consisting of T, A, E, and D, and T is optionally phosphorylated;
- X11 is selected from the group consisting K and R;
- and
- X12 is selected from the group consisting of P, A, and G.
14 more elements
Dependencies are inferred from the claim text.