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US 11,535,645 B2Granted
6-mercaptopurine nucleoside analogues
OwnerXibin Liaoinventor
Life of this patent
Estimating the term…
Abstract
A compound has the following formula (I) or formula (II), an isomer thereof, a tautomer thereof, a pharmaceutical acceptable solvate thereof, or a pharmaceutical acceptable prodrug thereof.
Claims7
A compound having the following formula (I), or a tautomer thereof:
- wherein
- X1 is —O— or —NH—;
- R7 is alkyl, alkyl substituted with one or more —OH or halo groups, alkenyl, alkenyl substituted with one or more —OH or halo groups, alkynyl, alkynyl substituted with one or more —OH or halo groups, cycloalkyl, cycloalkyl substituted with one or more —OH or halo groups, aryl, aryl substituted with one or more —OH, halo, —CN, —NO2, alkyl, alkoxy, or haloalkyl groups, benzyl, benzyl substituted with one or more —OH, halo, —CN, —NO2, alkyl, alkoxy, or haloalkyl groups, heteroaryl, heteroaryl substituted with one or more —OH, halo, —CN, —NO2, alkyl, alkoxy, or haloalkyl groups, heterocyclyl, heterocyclic substituted with one or more —OH, halo, —CN, —NO2, alkyl, alkoxy, or haloalkyl groups, —CH(CH3)COOCH(CH3)2
- R4 is —H, —OH, —CH3, —Cl, —F, —N3, —OCH3, alkenyl, or alkynyl;
- R5 is —H, —OH, —CH3, −Cl, —F, —N3, —OCH3, alkenyl, or alkynyl;
- and
- R10 is —L—M, wherein L is —O—, —O—CH2—, —S—, —NH—, —CO—, —SO—, or —CH2—, and M is alkyl, alkyl substituted with one or more —OH or halo groups, alkenyl, alkenyl substituted with one or more —OH or halo groups, alkynyl, alkynyl substituted with one or more -OH or halo groups, alkoxy, alkoxy substituted with one or more —OH or halo groups, cycloalkyl, cycloalkyl substituted with one or more —OH or halo groups, aryl, aryl substituted with one or more —OH, halo, —CN, —NO2, alkyl, alkoxy, or haloalkyl groups, benzyl, benzyl substituted with one or more —OH, halo, —CN, —NO2, alkyl, alkoxy, or haloalkyl groups, heteroaryl, heteroaryl substituted with one or more —OH, halo, —CN, —NO2, alkyl, alkoxy, or haloalkyl groups, heterocyclyl, or heterocyclic substituted with one or more —OH, halo, —CN, —NO2, alkyl, alkoxy, or haloalkyl groups.
4 more elements
A compound having the following formula (II), or a tautomer thereof:
- or a pharmaceutical acceptable solvate thereof,
- wherein
- X2 is —O— or —NH—;
- X3 is —O— or —NH—;
- X4 is —CH2— or nil;
- Y is —O—,—S—, or —SO2—;
- R8 and R9 are independently selected from the group consisting of alkyl, alkyl substituted with one or more —OH or halo groups, alkenyl, alkenyl substituted with one or more —OH or halo groups, alkynyl, alkynyl substituted with one or more —OH or halo groups, cycloalkyl, cycloalkyl substituted with one or more —OH or halo groups, aryl, aryl substituted with one or more —OH, halo, —CN, —NO2, alkyl, alkoxy, or haloalkyl groups, benzyl, benzyl substituted with one or more —OH, halo, —CN, —NO2, alkyl, alkoxy, or haloalkyl groups, heteroaryl, heteroaryl substituted with one or more —OH, halo, —CN, —NO2, alkyl, alkoxy, or haloalkyl groups, heterocyclyl, heterocyclic substituted with one or more —OH, halo, —CN, —NO2, alkyl, alkoxy, or haloalkyl groups, —CH(CH3)COOCH(CH3)
- or R8 and R9 form a five-membered or six-membered heterocyclo ring or a five-membered or six-membered heterocyclo ring substituted with one or more —OH, halo, —CN, —NO2, alkyl, alkoxy, benzyl, benzyl substituted with one or more —OH, halo, —CN, —NO2, alkyl, alkoxy, or haloalkyl groups, or haloalkyl groups;
- R4 is —H, —OH, —CH3, —Cl, —F, —N3, —OCH3, alkenyl, or alkynyl;
- R5 is —H, —OH, —CH3, —Cl, —F, —N3, —OCH3, alkenyl, or alkynyl;
- and
- R10 is —L—M, wherein L is ——O—, —O—CH2—, —S—, —NH—, —CO—, —SO—, or —CH2—, and M is alkyl, alkyl substituted with one or more —OH or halo groups, alkenyl, alkenyl substituted with one or more —OH or halo groups, alkynyl, alkynyl substituted with one or more —OH or halo groups, alkoxy, alkoxy substituted with one or more —OH or halo groups, cycloalkyl, cycloalkyl substituted with one or more —OH or halo groups, aryl, aryl substituted with one or more —OH, halo, —CN, —NO2, alkyl, alkoxy, or haloalkyl groups, benzyl, benzyl substituted with one or more —OH, halo, —CN, —NO2, alkyl, alkoxy, or haloalkyl groups, heteroaryl, heteroaryl substituted with one or more —OH, halo, —CN, —NO2, alkyl, alkoxy, or haloalkyl groups, heterocyclyl, or heterocyclic substituted with one or more —OH, halo, —CN, —NO2, alkyl, alkoxy, or haloalkyl groups.
9 more elements
Dependencies are inferred from the claim text.