Solid-state forms of Regadenoson, their use and preparation
AssigneeMacfarlan Smith Limited
InventorPadmini Kavuru
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Abstract
The invention relates to a crystalline methanol or dimethyl sulfoxide solvated form of regadenoson and an anhydrous polymorph of regadenoson. The invention is also directed to the preparation of the methanol or dimethyl sulfoxide solvated and anhydrous solid-state forms of regadenoson. In particular, the invention relates to the preparation of the anhydrous polymorph of regadenoson in a stable form from the dimethyl sulfoxide solvated form of regadenoson, which preparation is purifiable and scalable.
Claims13
A compound which is a crystalline methanol or dimethyl sulfoxide solvate of regadenoson.
A compound which is a crystalline Form I of anhydrous regadenoson having at least 2 or more X-ray powder diffraction peaks selected from about 5.0, 13.7, 24.0 and 27.0° 2θ, as measured by CuKα radiation or having a thermal event at about 250.8° C.
Dependencies are inferred from the claim text.