Pyrrolo[1,2-b] pyridazine derivatives
AssigneeGilead Sciences, Inc.
InventorsStephen Ammann, Elizabeth M. Bacon, Gediminas Brizgys, Elbert Chin, Chienhung Chou, Jeromy J. Cottell, Marilyn Ndukwe, James G. Taylor, Nathan E. Wright, Zheng-Yu Yang, Sheila M. Zipfel
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Abstract
A compound of Formula (I): pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof, wherein the variable substituents are disclosed herein.
Claims30
A method of treating an inflammatory condition selected from:
- rheumatoid arthritis (RA), inflammatory bowel disease (IBD), gout, Lyme disease, arthritis, psoriasis, pelvic inflammatory disease, systemic lupus erythematosus (SLE), Sjogren's syndrome, or, Psoriasis, in a patient in need thereof, comprising administering to said patient a compound of Formula (II):
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is H, D or methyl, R2 is H, D or methyl, or
- R1 and R2, together with the carbon atoms to which they are attached, form cyclopropyl.
The method of claim of 1 wherein the condition is pelvic inflammatory disease.
A method of treating an inflammatory condition selected from rheumatoid arthritis (RA), inflammatory bowel disease (IBD), gout, Lyme disease, arthritis, psoriasis, pelvic inflammatory disease, systemic lupus erythematosus (SLE), or Sjogren's syndrome, in a patient in need thereof, comprising administering to said patient the compound
- or a pharmaceutically acceptable salt thereof.
A method of treating an inflammatory condition selected from rheumatoid arthritis (RA), inflammatory bowel disease (IBD), gout, Lyme disease, arthritis, psoriasis, pelvic inflammatory disease, systemic lupus erythematosus (SLE), or Sjogren's syndrome, in a patient in need thereof, comprising administering to said patient a pharmaceutical composition comprising the compound:
- or a pharmaceutically acceptable salt thereof, together with at least one pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.