Histone demethylase inhibitors
AssigneeCelgene Quanticel Research, Inc.
InventorsAmogh Boloor, Toufike Kanouni, Jeffrey Alan Stafford, James Marvin Veal, Michael Brennan Wallace
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Abstract
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrido[3,4-d]pyrimidin-4-one derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.
Claims13
A compound of Formula (X), or pharmaceutically acceptable salt thereof,
- wherein,
- X is halogen and n is 0 or 1;
- ring A, represented by
- is chosen from:
- and R1 is alkyl, aryl, aralkyl, carbocyclyl, carbocyclylalkyl, —(C═O)aryl, or —(S02)aryl.
Dependencies are inferred from the claim text.