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US 11,535,597 B2Granted
Photoreactive ligands and uses thereof
AssigneeThe Scripps Research Institute
InventorsBenjamin F. Cravatt, Christopher G. Parker, Bruno Correia
Life of this patent
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Abstract
Disclosed herein are methods for identifying proteins as targets for interaction with a small molecule ligand. Also disclosed herein are small molecule ligands and compositions for use in profiling druggable proteins.
Claims3
A small molecule ligand having a structure represented by Formula (I):
- wherein R is
- and wherein the wavy lines indicate linkage to the carbonyl group of the structure of Formula (I).
A small molecule ligand which binds to a ligand binding site of Cathepsin B (CTSB), the small molecule ligand is, selected from the group consisting of
Dependencies are inferred from the claim text.