Isoquinoline sulfonyl chloride acid addition salts and method of manufacture thereof
AssigneeD. Western Therapeutics Institute, Inc.
InventorsKengo Sumi, Ryohei Nakamura
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Abstract
A compound, such as isoquinoline-6-sulfonyl chloride acid and/or addition salts thereof, may be useful as a manufacturing intermediate for an isoquinoline-6-sulfonamide compound. A method for manufacturing such compounds and/or or acid addition salts thereof, may involve subjecting 6-(benzylthio)isoquinoline to an oxidative chlorination reaction and/or reacting 6-aminoisoquinoline with a nitrite or nitrous acid ester, then with thionyl chloride, and then with an acid.
Claims17
A method for manufacturing isoquinoline-6-sulfonyl chloride and/or one or more acid addition salts thereof, the method comprising:
- subjecting 6-(benzylthio)isoquinoline to an oxidative chlorination reaction.
A method for manufacturing an isoquinoline-6-sulfonyl chloride acid addition salt, the method comprising:
- reacting 6-aminoisoquinoline with a nitrite or nitrous acid ester, then with thionyl chloride, and then with an acid.
6-(Benzylthio)isoquinoline.
Dependencies are inferred from the claim text.