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US 11,535,592 B2Granted
Antimicrobial compounds, compositions, and method
AssigneeUniversity of Kentucky Research Foundation
InventorsSylvie Garneau-Tsodikova, Octavio Alberto Gonzalez
Life of this patent
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Abstract
The presently-disclosed subject matter generally relates to antimicrobial compounds, compositions, methods of making and methods of use thereof. The presently-disclosed subject matter further relates to compounds, compositions and methods for the control of Porphyromonas gingivalis.
Claims21
A compound having the formula (I) or a pharmaceutically acceptable salt thereof:
- wherein,
- R1 is H or lower alkyl;
- W, Y, and Z are independently selected from H,
- and OR3, so long as only one of W, Y, and Z is
- and R2 and R3 are each independently selected from H or lower alkyl;
- and
- X is H, NO2, N(R4)2, or SO2R5 where R4 is H or lower alkyl, and R5 is H or lower alkyl;
- provided that, where R1 is lower alkyl, W is OR3, R3 is lower alkyl, Y is H, and Z is
- (i) when R2 is H;
- then X is H, NO2, N(R4)2, or SO2R5 where R4 is H or lower alkyl, and R5 is H or lower alkyl;
- and
- (ii) when R2 is lower alkyl;
- then X is N(R4)2 or SO2R5 where R4 is lower alkyl, and R5 is H or lower alkyl.
10 more elements
Dependencies are inferred from the claim text.