Microfluidic devices comprising electrochemical sensors
AssigneeBoard of Regents, The University of Texas System
InventorsHyejin Moon, Ali Farzbod
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Abstract
An electrowetting-on-dielectric (EWOD) microfluidic device comprises at least one integrated electrochemical sensor, the electrochemical sensor comprising: a reference electrode; a sensing electrode; and an analyte-selective layer positioned over the sensing electrode. In some embodiments, the electrochemical sensor measures a concentration of an analyte in a fluid sample exposed to the electrochemical sensor based on a potential difference between the reference electrode and the sensing electrode. The first analyte and the second analyte can be selected from a group consisting of K+, Na+, Ca2+, Cl−, HCO3−, Mg2+, H+, Ba2+, Pb2+, Cu2+, I−, NH4+, (SO4)2−.
Claims19
An electrowetting-on-dielectric (EWOD) microfluidic device comprising at least one integrated electrochemical sensor, wherein:
- the at least one integrated electrochemical sensor comprises:
- a reference electrode;
- a sensing electrode;
- and
- an analyte-selective layer positioned over the sensing electrode;
- the device comprises a first parallel plate;
- the first parallel plate comprises a first substrate, a first set of one or more electrowetting electrodes positioned over the first substrate, and a first dielectric layer positioned over the first set of one or more electrowetting electrodes and the first substrate;
- the reference electrode and the sensing electrode are embedded within the first dielectric layer but are not covered by the first dielectric layer;
- the reference electrode and the sensing electrode are in electrical communication with the first set of one or more electrowetting electrodes of the first parallel plate;
- a first hydrophobic coating is positioned over the first dielectric layer;
- the reference electrode is disposed in a reference electrode borehole extending through the first dielectric layer and the first hydrophobic coating to the first set of one or more electrowetting electrodes positioned over the first substrate;
- and
- the sensing electrode is disposed in a sensing electrode borehole extending through the first dielectric layer and the first hydrophobic coating to the first set of one or more electrowetting electrodes positioned over the first substrate.
Dependencies are inferred from the claim text.