High-frequency low duty cycle patterns for neural regulation
AssigneeReshape Lifesciences Inc.
InventorsJonathan J. Waataja, Adrianus P. Donders
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Abstract
A method of downregulating and/or upregulating neural activity by applying a high frequency alternating current electrical signal to a nerve in a subject is disclosed. The signal comprises more than one microsecond cycle comprising one or more periods, each period comprising a charge recharge phase, and optionally, a pulse delay, each period having a frequency of at least 1000 Hz; and a microsecond inactive phase. In embodiments, an electrical signal treatment comprises more than one microsecond cycle to form a millisecond cycle, each millisecond cycle separated by a millisecond inactive phase during an on time. In embodiments, the electrical signal patterns can differ in amplitude.
Claims11
A method of applying an electrical signal having parameters that downregulate nerve activity to a nerve in a subject, the method comprising:
- connecting a therapy system to a nerve of a subject, and
- applying the electrical signal to the nerve during an on time, wherein the electrical signal comprises more than one millisecond active phases and at least one millisecond inactive phase, wherein each one of the millisecond active phases is separated by at least one of the at least millisecond inactive phases during the on time, wherein each one of the millisecond active phases comprises at least one microsecond cycle, wherein each of the at least one microsecond cycle comprises at least one period and at least one microsecond inactive phase, wherein each of the at least one period comprises a charge phase and a recharge phase, wherein the electrical signal has a frequency of the period of at least 200 Hz.
Dependencies are inferred from the claim text.