Systems and methods for drug delivery, treatment, and monitoring

An implantable delivery system, comprising:

• a percutaneous access device through which drug-containing fluid can be delivered, the access device including a plurality of ports;
• a trunk line having a plurality of independent fluid lumens extending therethrough, the plurality of fluid lumens being in fluid communication with corresponding ones of the plurality of ports formed in the access device;
• a manifold comprising a body configured to be secured to a skull of a patient and having an inlet port for the trunk line and a plurality of outlet ports;
• a plurality of branch lines connected to the plurality of outlet ports of the manifold, the manifold configured to route the plurality of fluid lumens in the trunk line into the plurality of branch lines, each branch line of the plurality of branch lines including one or more fluid lumens of the plurality of fluid lumens disposed therein;
• a skull anchor configured to be secured to the skull of a patient, the skull anchor spaced from the manifold;
• and
• a plurality of microfluidic catheters configured to extend into the brain of a patient, the skull anchor being configured to couple the plurality of branch lines to corresponding ones of the plurality of microfluidic catheters;
• wherein at least one of the plurality of microfluidic catheters comprises:
• a micro-tip having a proximal portion, a central portion, a distal portion, and at least one fluid channel extending along said proximal, central, and distal portions, the at least one fluid channel having an outlet port at a distal end thereof and an inlet port at a proximal end thereof;
• a first outer sheath disposed coaxially over the distal portion of the micro-tip such that the distal portion of the micro-tip protrudes from a distal end of the first outer sheath;
• a first tissue-receiving space defined between an exterior surface of the micro-tip and an interior surface of the distal end of the first outer sheath;
• a catheter body extending proximally from the micro-tip such that the at least one fluid channel of the micro-tip is in fluid communication with a respective inner lumen of the catheter body;
• and
• a nose portion disposed over at least the central portion of the micro-tip and extending between the first outer sheath and the catheter body such that the nose portion defines an exterior surface that tapers from a reduced distal diameter corresponding to the outside diameter of the first outer sheath to an enlarged proximal diameter corresponding to the outside diameter of the catheter body.