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US 11,534,569 B2Granted
Combination devices, systems, and methods for humidification of the airways and high efficiency delivery of pharmaceutical aerosols
AssigneeVirginia Commonwealth University
InventorsPhilip Worth Longest, Jr., Michael Hindle, Benjamin Spence, Sneha Dhapare, Wei Xiangyin
Life of this patent
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Abstract
Devices, systems, and methods are disclosed which permit ventilation therapy concurrent with humidity and aerosol drug delivery. Exemplary mixer-heaters employ alternating actuation of humidity and drug nebulizers and may use a single constant power setting for the heating section while keeping a controlled outlet temperature over the course of treatment.
Claims20
A drug delivery system, comprising
- a first nebulizer configured to intermittently produce a humidity stream;
- a second nebulizer configured to intermittently produce a drug aerosol stream;
- a mixer-heater comprising
- a mixing section configured to combine the humidity stream and the drug aerosol stream with a ventilation stream to produce a combination stream, and
- a heating section configured to be operated at a constant power setting without heating the combination stream above 42° C.;
- a patient interface configured for delivering the combination stream to a patient;
- and
- one or more conduits fluidically connecting the mixer-heater with the patient interface;
- wherein a volume of the mixer-heater, a volume of the one or more conduits, and a volume of the patient interface add up to a system volume of 150 mL or less.
6 more elements
A method of drug delivery with ventilation therapy, comprising
- intermittently producing a humidity stream with a first nebulizer;
- intermittently producing a drug aerosol stream with a second nebulizer, wherein the humidity stream and drug aerosol stream are produced in alternating intervals;
- with a mixer-heater,
- mixing the humidity stream and the drug aerosol stream with a ventilation stream to produce a combination stream, and
- heating the combination stream to a temperature not exceeding 42° C. with a heating section operated at a constant power setting;
- and
- delivering the combination stream to a patient using a patient interface and one or more conduits,
- wherein the combining, mixing, heating, and delivering steps use 150 mL or less total system volume.
5 more elements
Dependencies are inferred from the claim text.