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US 11,534,530 B2Granted
Systems for and methods for using biomimetic structures providing communication in living tissue
AssigneeThe General Hospital Corporation
InventorJoseph P. Vacanti
Life of this patent
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Abstract
A platform for creating engineered tissues includes a vascular tube that defines a vascular diameter and is configured to receive vascular system seed cells, a non vascular tube that defines a non-vascular tube diameter and is configured to receive organ system seed cells, and a barrier formed between the vascular tube and the non vascular tube.
Claims19
An artificial organ comprising:
- a tubular structure comprising a branching structure comprising:
- a plurality of vascular tubes configured to receive a first plurality of viable cells;
- a plurality of non-vascular tubes configured to receive a second plurality of viable cells, wherein:
- the tubular structure is a monolithic three-dimensional portion of the artificial organ,
- the plurality of vascular tubes and the plurality of non-vascular tubes are arranged relative to each other to provide an interface between the plurality of vascular tubes and the plurality of non-vascular tubes, and
- a barrier formed at the interface between the plurality of vascular tubes and the plurality of non-vascular tubes, wherein the barrier comprises a characteristic width in accordance with the interface to allow a degree of fluidic communication between the plurality of vascular tubes and the plurality of non-vascular tubes.
3 more elements
Dependencies are inferred from the claim text.