Pectin-carboxymethylcellulose mesothelial sealants and protectants
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsSteven James Mentzer, Cristian David Valenzuela, Alexandra Brooke Ysasi, Andrew Barrett Servais
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Abstract
This disclosure relates to pectin-based polymer compositions and methods of use thereof to cover, protect, and seal injuries, e.g., surgical wounds, in a mesothelial tissue. The methods include obtaining a bioadhesive pectin-based polymer composition including a complex of high-methoxyl pectin (HMP) and carboxymethylcellulose (CMC) in a ratio from about 10 to 1 to 1 to 10 by weight; applying the composition to an injured mesothelial tissue; and applying pressure for at least one minute to enable the composition to bind to the mesothelial tissue.
Claims18
A method of covering and sealing a wound in a mesothelial tissue of a lung, the method comprising:
- (a) providing a bioadhesive pectin-based polymer film comprising:
- i) a pectin selected from 100 wt % high-methoxyl pectin (HMP), and ii) water;
- (b) applying the film to the wound in the mesothelial tissue of the lung;
- and
- (c) applying pressure for at least one minute to enable the film to bind to the wound in the mesothelial tissue of the lung.
Dependencies are inferred from the claim text.