Back to results
US 11,534,506 B2Granted
Methods for cell labeling and medical imaging
AssigneeMayo Foundation for Medical Education and Research
InventorsAditya Bansal, Timothy R. DeGrado, Mukesh K. Pandey
Life of this patent
Estimating the term…
Abstract
Methods of ex vivo labeling of a biological material for in vivo imaging, methods of labeling a biological material in vivo, methods for preparing a labeling agent, and methods for in vivo imaging of a subject using a biological material labeled with a labeling agent are disclosed. In one non-limiting example, the biological material is selected from cells and the labeling agent is a 89Zr-Desferrioxamine-NCS labeling agent.
Claims17
A biological material selected from stem cells, the biological material being labeled with a labeling agent comprising:
- a chelating moiety, a conjugation moiety, and at least one of (i) a radionuclide and (ii) a paramagnetic metal ion or compound,
- wherein the chelating moiety includes a hydroxamic acid group and the conjugation moiety includes an isothiocyanate group, and
- wherein the isothiocyanate group of the labeling agent binds to the biological material.
Dependencies are inferred from the claim text.