Polyglutamated antifolates and uses thereof
AssigneeL.E.A.F. Holdings Group LLC
InventorsClet Niyikiza, Victor Mandla Moyo
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Abstract
The disclosure relates generally to polyglutamated antifolates, formulations containing liposomes filled with the polyglutamated antifolates, methods of making the polyglutamated antifolates and liposome containing formulations, and methods of using the polyglutamated antifolates and liposome containing formulations to treat hyperproliferative disorders (e.g., cancer) and disorders of the immune system (e.g., an autoimmune disease such as rheumatoid arthritis).
Claims27
A liposomal polyglutamated antifolate composition comprising a polyglutamated antifolate encapsulated by a liposome, wherein the polyglutamated antifolate comprises at least 3 glutamate residues linked by their gamma carboxyl groups, wherein the liposome is pegylated and does not contain a targeting moiety having specific affinity for a surface antigen on a target cell.
A liposomal polyglutamated antifolate composition comprising a polyglutamated antifolate encapsulated by a liposome, wherein the polyglutamated antifolate comprises at least 3 glutamate residues linked by their gamma carboxyl groups, and wherein the liposome does not contain a targeting moiety having specific affinity for a surface antigen on a target cell.
Dependencies are inferred from the claim text.