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US 11,534,497 B2Granted
Compositions and methods for delivery of RNA
AssigneeHDT Bio Corp.
InventorsAmit Khandhar, Steven Reed, Malcolm Duthie, Jesse Erasmus, Darrick Carter, Bryan J. Berube
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Abstract
The disclosure provides nanoemulsion compositions and methods of making and using thereof to deliver a bioactive agent such as a nucleic acid to a subject. The nanoemulsion composition comprises a hydrophobic core based on inorganic nanoparticles in a lipid nanoparticle that allows imaging as well as delivering nucleic acids. Methods of using these particles for treatment and vaccination are also provided.
Claims30
A method for generating an immune response in a subject, comprising administering to a subject:
- a composition, wherein the composition comprises:
- nucleic acids, wherein the nucleic acids comprise sequence encoding for:
- an RNA polymerase complex region from an RNA virus;
- and
- a SARS-CoV-2 spike protein region;
- and
- lipid nanoparticles, wherein the lipid nanoparticles comprise:
- a surface comprising cationic lipids;
- and
- a hydrophobic core, and
- wherein the nucleic acids are complexed to the cationic lipids to form nucleic acid-lipid nanoparticle complexes.
8 more elements
Dependencies are inferred from the claim text.