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US 11,534,495 B2Granted
Tissue factor-targeted antibody-drug conjugate
AssigneesFudan University, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai Miracogen Inc.
InventorsKe Yu, Jingkang Shen, Tao Meng, Lanping Ma, Xuesai Zhang, Qingrou Li, Qing Lin
Life of this patent
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Abstract
A tissue factor (TF)-targeted antibody-drug conjugate (ADC) and a method for preparing the ADC. The ADC is capable of binding to TF antigen with high specificity, and has high affinity, low immunogenicity, high cytotoxicity, and significant anti-tumor activity.
Claims10
An antibody-drug conjugate, wherein the antibody-drug conjugate comprises:
- (a) an antibody moiety;
- and
- (b) a conjugation moiety conjugated to the antibody moiety, wherein the conjugation moiety is selected from the group consisting of:
- (i) Maytansine derivatives (DM1, DM4), auristatin and dolastatin;
- and
- (ii) Monomethyl auristatin E (MMAE), Monomethyl auristatin F (MMAF), Monomethyl Dolastatin 10 (MMAD) derivatives or a combination thereof;
- wherein the heavy chain variable region of the antibody comprises the following three complementary determining regions (CDRs):
- (H1) CDR1 as set forth in SEQ ID NO:
- 1,
- (H2) CDR2 as set forth in SEQ ID NO:
- 2, and
- (H3) CDR3 as set forth in SEQ ID NO:
- 3;
- and
- the light chain variable region of the antibody comprises the following three complementary determining regions (CDRs):
- (L1) CDR1′ as set forth in SEQ ID NO:
- 4,
- (L2) CDR2′ as set forth in SEQ ID NO:
- 5, and
- (L3) CDR3′ as set forth in SEQ ID NO:
- 6.
18 more elements
Dependencies are inferred from the claim text.